Description

3-Trifluoromethylbenzoic Anhydride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its value lies in its role as a versatile acylating agent, enabling the efficient introduction of the trifluoromethylbenzoate moiety, a key structural feature known to enhance the metabolic stability and lipophilicity of target molecules. This compound is critically needed by research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty materials sectors for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylated aromatic system to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a critical intermediate in the manufacture of fluorinated compounds for electronic display and lighting applications.
• Polymer Modification: Employed as a monomer or cross-linking agent to introduce fluorinated aromatic units into polymer chains, enhancing chemical resistance and thermal stability.
• Organic Synthesis Reagent: A valuable acylating agent in academic and industrial research for preparing esters, amides, and other derivatives under mild conditions.
• Dye & Pigment Manufacturing: Used in the synthesis of specialized fluorinated dyes and pigments that offer unique color fastness and stability properties.

Basic Information

Product Name	3-Trifluoromethylbenzoic Anhydride
CAS No.	25753-15-5
Molecular Formula	C16H8F6O3
Molecular Weight	362.23 g/mol
Synonyms	3-(Trifluoromethyl)benzoic anhydride; Benzoic acid, 3-(trifluoromethyl)-, 1,1'-anhydride; m-Trifluoromethylbenzoic anhydride; α,α,α-Trifluoro-m-toluic anhydride; 3-Trifluoromethylbenzoyl anhydride; 3-Carboxybenzotrifluoride anhydride; 3-TFMBA; TFMBA anhydride
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethylbenzoic Anhydride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all commercial shipments. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.