Description

cis-Dothiepin Hydrochloride is a high-purity pharmaceutical intermediate and reference standard of significant importance in medicinal chemistry and analytical research. Its primary value lies in its role as a key stereoisomer for the development and quality control of tricyclic antidepressant compounds. This product is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers requiring a precise chemical building block for synthesis or a certified standard for method validation and impurity profiling.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of tricyclic antidepressant drugs.
• Analytical Reference Standard: Used for method development, validation, and quantification in HPLC, GC, and other chromatographic assays.
• Impurity Standard: Serves as a certified reference material (CRM) for identifying and controlling stereoisomeric impurities in active pharmaceutical ingredients (APIs).
• Pharmacological Research: Employed in preclinical studies to investigate structure-activity relationships (SAR) and metabolic pathways.
• Quality Control (QC) Testing: Essential for in-house quality assurance protocols in pharmaceutical manufacturing to ensure batch consistency and purity.
• Regulatory Compliance: Supports documentation for regulatory submissions (e.g., to FDA, EMA) requiring detailed impurity profiles and characterization data.

Basic Information

Product Name	cis-Dothiepin Hydrochloride
CAS No.	25627-39-8
Molecular Formula	C19H21NS•HCl
Molecular Weight	331.90 g/mol
Synonyms	cis-Dosulepin Hydrochloride; (3Z)-3-(6H-Benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine Hydrochloride; Prothiaden (cis-isomer); Dothiepin Hydrochloride (cis-); 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]thiepin Hydrochloride (cis-); cis-Isomer of Dothiepin HCl
EINECS	Contact for details

Quality Control

Our cis-Dothiepin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile determination via advanced techniques like HPLC and NMR to ensure it meets high-purity standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.