Description

4-Fluorobenzoic Anhydride is a high-purity fluorinated aromatic anhydride, a key building block in advanced organic synthesis. This compound is essential for introducing the 4-fluorobenzoyl moiety, a critical structural motif known to enhance the metabolic stability and binding affinity of target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and biological activity.
• Liquid Crystal & Polymer Chemistry: Serves as a monomer or modifying agent for creating fluorinated polyimides, polyesters, and liquid crystal polymers with enhanced thermal stability and optical properties.
• Peptide & Protein Modification: Employed as an acylating agent to modify amino groups, facilitating the study of protein structure-function relationships and the development of peptide-based therapeutics.
• Material Science Research: Key reagent for synthesizing fluorinated organic semiconductors, dielectric materials, and other advanced electronic materials.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized fluorinated dyes and pigments with unique color fastness and spectral characteristics.

Basic Information

Product Name	4-Fluorobenzoic Anhydride
CAS No.	25569-77-1
Molecular Formula	C14H8F2O3
Molecular Weight	262.21 g/mol
Synonyms	Bis(4-fluorobenzoyl) anhydride; 4-Fluorobenzoic acid anhydride; p-Fluorobenzoic anhydride; 4-Fluorobenzoic anhydride; 4-Fluorobenzenecarboxylic acid anhydride; (4-Fluorobenzoyl) anhydride; 1,1'-(Oxydicarbonyl)bis(4-fluorobenzene)
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzoic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and hydrolysis. Keep away from strong bases, strong oxidizing agents, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.