Description

Trazodone Hydrochloride CAS NO 25332-39-2 is a high-purity pharmaceutical active ingredient (API) belonging to the class of serotonin antagonist and reuptake inhibitors (SARIs). It is a critical intermediate and active substance used in the manufacture of antidepressant medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for major depressive disorder, anxiety, and insomnia. We supply this material with a focus on stringent quality control to meet the exacting standards of the global pharmaceutical industry.

Application

• Pharmaceutical API Manufacturing: Primary active ingredient in the formulation of antidepressant and anxiolytic tablets and capsules.
• Generic Drug Production: Sourcing for manufacturers producing bioequivalent versions of branded trazodone medications.
• Clinical Research & Development: Used as a reference standard or raw material in preclinical and clinical studies for new CNS therapies.
• Analytical & Quality Control: Serves as a certified reference material (CRM) for HPLC, UV, and other analytical method development and validation.
• Veterinary Pharmaceutical Applications: Potential use in compounding medications for animal behavioral disorders under veterinary guidance.

Basic Information

Product Name	Trazodone Hydrochloride
CAS No.	25332-39-2
Molecular Formula	C19H22ClN5O·HCl
Molecular Weight	408.33 g/mol
Synonyms	2-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride; Trazodone HCl; AF-1161; Trittico; Desyrel; Molipaxin; Thombran; Trazorel; Mesyrel
EINECS	Contact for details

Quality Control

Our Trazodone Hydrochloride is manufactured and tested under a quality management system. Each batch is subjected to rigorous analytical testing to ensure identity, purity, and consistency, meeting standards suitable for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, related substances, residual solvents, and other critical parameters. We can support compliance with USP, EP, and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.2%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.