Description

(2S)-2-Phenylaziridine is a chiral, non-racemic aziridine derivative, a versatile and high-value building block in organic synthesis. Its strained three-membered ring structure makes it a powerful electrophile for the stereoselective introduction of a phenethylamine moiety, enabling the construction of complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-amino alcohols, antidepressants, and other neurologically active compounds.
• Asymmetric Catalysis: Used as a ligand precursor or a chiral auxiliary in transition metal-catalyzed reactions.
• Polymer Chemistry: Monomer for the synthesis of functionalized polymers with tailored properties via ring-opening polymerization.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators.
• Peptidomimetics Research: Employed in the design and synthesis of conformationally constrained peptide analogs.
• Material Science: Precursor for surface modification and the creation of advanced organic frameworks.

Basic Information

Product Name	(2S)-2-Phenylaziridine
CAS No.	25260-42-8
Molecular Formula	C8H9N
Molecular Weight	119.16 g/mol
Synonyms	(S)-2-Phenylaziridine; (S)-2-Phenylazacyclopropane; (S)-Phenethylamine N-ethylene; (S)-Styrene imine; (-)-(S)-2-Phenylaziridine; (2S)-2-Phenylaziridine; Aziridine, 2-phenyl-, (2S)-; (S)-N-Phenylethylenimine
EINECS	Contact for details

Quality Control

Our (2S)-2-Phenylaziridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for assay, enantiomeric excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. The product is moisture-sensitive and should be handled under dry conditions to prevent hydrolysis of the aziridine ring.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.