Description

2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine Hydrochloride is a high-purity nucleoside analog hydrochloride salt, a critical building block in advanced pharmaceutical research and development. Its primary value lies in its role as a key intermediate for the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of modified oligonucleotides and prodrugs. This compound is essential for research institutions, pharmaceutical companies, and CDMOs engaged in the discovery and manufacturing of next-generation nucleotide-based drugs targeting a range of viral and oncological indications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of antiviral agents, especially for hepatitis B (HBV) and other viral infections.
• Anticancer Drug Development: Serves as a building block for nucleotide analogs used in chemotherapy and targeted cancer therapies.
• Oligonucleotide Synthesis: Used in the production of modified antisense oligonucleotides and siRNA for genetic research and therapeutic applications.
• Prodrug Synthesis: Key starting material for creating prodrug forms of nucleoside analogs to improve bioavailability and pharmacokinetics.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a reference standard in analytical laboratories.
• Process Development & Scale-up: Used by contract development and manufacturing organizations (CDMOs) for process optimization and cGMP manufacturing.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine Hydrochloride
CAS No.	25183-22-6
Molecular Formula	C9H13FN3O4 • HCl
Molecular Weight	285.68 g/mol (Free base: 246.22 g/mol)
Synonyms	2'-Fluoro-2'-deoxyarabinocytidine hydrochloride; 2'-F-ara-C HCl; 2'-Deoxy-2'-fluoro-β-D-arabinofuranosylcytosine hydrochloride; β-2'-Fluoro-2'-deoxyarabinocytidine HCl; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine hydrochloride; FdAraC HCl; 2'-F-dAraC HCl; 2'-Fluoro-arabinocytidine HCl
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines and can supply material that meets the specifications required for advanced R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.