Description

Desmethylphalloin is a naturally occurring cyclic peptide toxin, a derivative of the phallotoxin family. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as an inhibitor of actin polymerization. It serves as a critical reference standard and research tool for scientists studying cytoskeletal dynamics, toxicology, and the development of molecular probes. Key users include research institutions, pharmaceutical R&D departments, and biotechnology companies focused on cell biology and toxin-related studies.

Application

• Biochemical Research: Used as a high-purity reference standard for the study of phallotoxins and their mechanisms of action.
• Pharmacological Studies: Employed in in vitro and cell-based assays to investigate its effects on actin filament stability and cell morphology.
• Toxicology Research: Serves as a model compound for understanding the toxicology of amatoxins and phallotoxins, aiding in the study of mushroom poisoning.
• Drug Discovery: Acts as a molecular tool or lead compound in programs targeting the cytoskeleton for potential therapeutic applications.
• Analytical Chemistry: Utilized as a certified standard for the development and validation of analytical methods (e.g., HPLC, LC-MS) for toxin detection.
• Academic Research: Fundamental research tool in university laboratories for studies in biochemistry, cell biology, and natural product chemistry.

Basic Information

Product Name	Desmethylphalloin
CAS No.	25030-32-4
Molecular Formula	C34H48N8O11S
Molecular Weight	776.86 g/mol
Synonyms	O-Methyl-γ-amanitin; 6'-O-Methyl-γ-amanitin; 6'-O-Methyl-γ-amanitin; Desmethylphalloin; NSC 177461; γ-Amanitin 6'-methyl ether; (2S)-2-[[(2S,4R,6R)-6-[[(2S)-5,5-Dimethyl-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2S)-2-Amino-2-oxoethyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-hydroxy-2,5,7,10-tetramethyl-4,9-dioxo-1-oxa-8,11-diazacyclotetradec-12-en-3-yl]oxy]-3-(4-hydroxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Desmethylphalloin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.