Description

Aminocyclopentane-1-Carboxylic Acid, 1-[Carboxyl-14C] is a carbon-14 labeled derivative of a conformationally restricted β-amino acid, serving as a critical tool for advanced metabolic and pharmacokinetic research. This radiolabeled compound enables precise tracking and quantification in biological systems, providing invaluable data for drug discovery and development. It is essential for researchers in pharmaceutical R&D, agrochemical science, and biochemistry who require high-specific-activity tracers for autoradiography, ADME studies, and metabolic pathway elucidation.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of novel pharmaceutical candidates.
• Metabolic Pathway Analysis: Enables the detailed mapping of biochemical pathways in plants, animals, and microorganisms through tracer techniques.
• Autoradiography and Imaging: Serves as a precursor for synthesizing labeled compounds used in whole-body autoradiography (WBA) and other imaging modalities to visualize compound localization.
• Environmental Fate Studies: Applied in agrochemical research to trace the degradation, translocation, and binding of active ingredients in soil and plant systems.
• Biochemical Research: Acts as a building block for synthesizing labeled peptides or peptidomimetics to study protein interactions and enzyme mechanisms.
• Reference Standard: Provides an authenticated standard for the development and validation of analytical methods (e.g., LC-MS, HPLC) for non-labeled analogs.

Basic Information

Product Name	Aminocyclopentane-1-Carboxylic Acid, 1-[Carboxyl-14C]
CAS No.	24921-47-9
Molecular Formula	C6H11NO2 (with 14C label at the 1-carboxyl position)
Molecular Weight	~129.16 g/mol (exact mass depends on 14C enrichment)
Synonyms	1-Aminocyclopentane-1-carboxylic-1-14C acid; (1-14C)-1-Aminocyclopentanecarboxylic acid; 1-14C-ACPC; 1-Amino-1-carboxycyclopentane-1-14C; β-Aminocyclopentanecarboxylic-1-14C acid; ACC-1-14C; Cycloleucine-1-14C analog
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled materials is produced and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the exacting requirements of research applications. Comprehensive analysis includes HPLC with radiometric detection, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, radioactivity concentration, and solvent composition. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage of solutions, keep frozen and avoid repeated freeze-thaw cycles. All handling must comply with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC, MS)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radioactivity Concentration	As per customer requirement (e.g., 1 mCi/mL)
Solvent	Specified (e.g., Ethanol:Water mixture)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.