Description

7-Hydroxy Warfarin β-D-Glucuronide is a key glucuronide metabolite of the anticoagulant drug warfarin. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in developing and monitoring anticoagulant therapies.

Application

• Metabolite Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of warfarin metabolites in biological matrices.
• Pharmacokinetic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathways and clearance mechanisms of warfarin.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring (TDM) and clinical research.
• Drug-Drug Interaction Research: Employed to investigate potential interactions that may affect the metabolic conjugation and efficacy of warfarin.
• Enzyme Activity Assays: Used as a substrate in studies to assess the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control of warfarin sodium active pharmaceutical ingredient (API) and related formulations.

Basic Information

Product Name	7-Hydroxy Warfarin β-D-Glucuronide
CAS No.	24579-17-7
Molecular Formula	C26H32O11
Molecular Weight	520.53 g/mol
Synonyms	7-Hydroxywarfarin β-D-Glucuronide; 7-Hydroxywarfarin Glucuronide; Warfarin 7-O-β-D-Glucuronide; (S)-Warfarin 7-β-D-Glucuronide; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 7-(β-D-Glucopyranosiduronic Acid); 7-Hydroxy Coumadin Glucuronide
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Warfarin β-D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, spectroscopic identification (NMR, MS), and determination of residual solvents and moisture content to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.