Description

o-(4-Hydroxy-3,5-Di(125I)Iodophenyl)-3,5-Di(125I)Iodo-L-Tyrosine is a specialized, high-specific-activity radiochemical compound primarily used as a radiolabeled tracer in advanced biomedical research. Its core value lies in providing a precise tool for studying and quantifying biological processes, particularly those involving thyroid hormone metabolism and receptor binding. This compound is essential for researchers and pharmaceutical developers in the fields of nuclear medicine, radiopharmaceutical development, and endocrinology who require reliable, high-purity radioligands for in vitro and in vivo studies.

Application

• Radioligand Binding Assays (RLBA): Used as a high-affinity tracer for studying the binding characteristics of thyroid hormone receptors and related proteins.
• Metabolic Pathway Tracing: Enables the detailed tracking and quantification of thyroid hormone synthesis, transport, and degradation pathways in research models.
• Pharmaceutical Development: Serves as a critical tool in the discovery and screening of novel therapeutics targeting thyroid hormone pathways.
• Diagnostic Probe Development: Acts as a precursor or reference standard in the research and development of potential diagnostic imaging agents.
• In Vitro Diagnostics (IVD): Employed in the development and calibration of specialized immunoassays for thyroid function and related biomarkers.
• Autoradiography Studies: Provides a high-resolution radiolabel for locating and quantifying receptor distribution in tissue sections.

Basic Information

Item	Detail
Product Name	o-(4-Hydroxy-3,5-Di(125I)Iodophenyl)-3,5-Di(125I)Iodo-L-Tyrosine
CAS No.	24486-40-6
Molecular Formula	C15H9125I4NO4
Molecular Weight	Contact for details (Variable based on 125I specific activity)
Synonyms	3,5-Diiodo-L-thyronine, [125I]T2; L-3,5-Diiodothyronine, radiolabeled; [125I]3,5-T2; 3,5-Diiodo-L-thyronine (125I-labeled); o-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine, iodine-125 labeled; Radiolabeled 3,5-T2; 3,5-Diiodothyronine-125I; T2 (125I)
EINECS	Contact for details

Quality Control

Every batch of o-(4-Hydroxy-3,5-Di(125I)Iodophenyl)-3,5-Di(125I)Iodo-L-Tyrosine is manufactured and controlled under strict radiochemical purity standards. Quality is assured through comprehensive analytical techniques including HPLC and thin-layer chromatography (TLC) to verify radiochemical purity and specific activity. A Certificate of Analysis (COA) detailing radionuclidic purity, radiochemical purity, specific activity, and solvent composition is provided with each shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For optimal stability, store frozen at or below -20°C. The product is supplied in a suitable radiation-shielded container. Store in accordance with all local and national regulations for radioactive materials. Allow to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	> 2000 Ci/mmol (74 TBq/mmol)
Radionuclidic Purity	≥ 99% 125I at time of calibration
Solvent	Ethanol:Water or custom buffer (as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.