Description

(S)-Mandelamide CAS NO 24008-63-7 is a high-purity, single-enantiomer chiral building block and intermediate of significant importance in asymmetric synthesis. Its value lies in its utility for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high optical purity for their synthetic pathways.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drugs, particularly those targeting neurological and cardiovascular conditions.
• Asymmetric Synthesis: Used as a versatile building block for constructing complex molecules with defined stereocenters via reactions like nucleophilic additions or resolutions.
• Agrochemical Research: Intermediate in the development of chiral pesticides and herbicides where specific stereochemistry affects biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chiral ligands used in metal-catalyzed asymmetric transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(S)-Mandelamide
CAS No.	24008-63-7
Molecular Formula	C8H9NO2
Molecular Weight	151.16 g/mol
Synonyms	(S)-2-Hydroxy-2-phenylacetamide; (S)-(-)-Mandelamide; L-Mandelamide; (S)-α-Hydroxybenzeneacetamide; (2S)-2-Hydroxy-2-phenylacetamide; (S)-2-Phenylglycolamide; AMY40306; (S)-Mandelic acid amide
EINECS	Contact for details

Quality Control

Our (S)-Mandelamide is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.