Description

8,9-Dehydro-17-Estradiol-D3 is a deuterium-labeled derivative of a key steroidal estrogen metabolite, serving as a critical internal standard for precise analytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in sensitive bioanalytical methods. It is primarily utilized by research institutions, pharmaceutical developers, and clinical diagnostic laboratories engaged in hormone metabolism studies, pharmacokinetic research, and method validation.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous estradiol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Biomedical Research: Used in studies investigating estrogen metabolism, endocrine pathways, and the pharmacokinetics of steroidal compounds.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for hormone level monitoring in clinical settings.
• Pharmaceutical Development: Critical for drug metabolism and pharmacokinetic (DMPK) studies of estrogen-based therapeutics.
• Forensic Toxicology: Aids in the precise detection and confirmation of steroid hormones in forensic analyses.
• Quality Control Reference: Serves as a certified reference material for calibrating analytical instruments and validating laboratory methods.

Basic Information

Product Name	8,9-Dehydro-17-Estradiol-D3
CAS No.	23392-54-3
Molecular Formula	C18H21D3O2
Molecular Weight	275.40 g/mol
Synonyms	8,9-Dehydro-17β-estradiol-d3; 8,9-Dehydroestra-1,3,5(10)-triene-3,17β-diol-d3; 8,9-Dehydroestradiol-d3; 17β-Estradiol-8,9-dehydro-d3; Deuterated 8,9-Dehydroestradiol; [D3]-8,9-Dehydro-17β-estradiol; Estra-1,3,5(10)-triene-3,17β-diol-8,9-dehydro-d3
EINECS	Contact for details

Quality Control

Our 8,9-Dehydro-17-Estradiol-D3 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), chemical purity, isotopic purity (D-content), and specific tests. We adhere to relevant guidelines for reference standards to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. Keep the container in a dry, cool, and well-ventilated area. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity	≥ 95.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.