Description

D-Mannose, [2-3H] is a tritium-labeled isotopologue of the monosaccharide D-Mannose, specifically labeled at the 2-position. This compound is a critical tool for advanced biochemical and pharmacological research, enabling precise metabolic tracing and receptor binding studies. It is essential for researchers and developers in the fields of radiopharmaceutical development, glycobiology, and metabolic pathway analysis who require high-specific-activity tracers.

Application

• Metabolic Tracer Studies: Used to investigate the uptake, distribution, and metabolism of D-mannose in biological systems, including studies related to glycosylation disorders.
• Radiopharmaceutical Precursor: Serves as a labeled precursor in the research and development of novel diagnostic imaging agents for positron emission tomography (PET), following appropriate isotopic conversion.
• Glycobiology Research: Enables the study of mannose-specific lectin interactions, cell-surface carbohydrate recognition, and intracellular trafficking of glycoproteins.
• Drug Discovery & Development: Utilized in absorption, distribution, metabolism, and excretion (ADME) studies for drug candidates targeting carbohydrate-mediated processes.
• Enzyme Mechanism Studies: Acts as a substrate for investigating the kinetics and mechanisms of enzymes like phosphomannose isomerase and mannose kinases.

Basic Information

Product Name	D-Mannose, [2-3H]
CAS No.	23345-89-3
Molecular Formula	C6H113HO6
Molecular Weight	~181.16 g/mol (for C6H12O6)
Synonyms	2-Tritio-D-mannose; [2-3H]Mannose; D-[2-3H]Mannose; Tritium-labeled D-Mannose; Mannose-2-t; (2R,3S,4S,5S)-2,3,4,5,6-Pentahydroxyhexanal-2-t; Carubinose-2-t; Seminose-2-t
EINECS	Contact for details

Quality Control

Every batch of D-Mannose, [2-3H] is produced and analyzed under strict quality systems to ensure traceability and reliability for research applications. Certificates of Analysis (COA) are provided, detailing critical parameters such as radiochemical purity, specific activity, and chemical purity as determined by HPLC and radio-HPLC. Our quality commitment aligns with the standards required for fine chemicals and radiochemicals in research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as specified on the label. For long-term storage, keep in a dedicated, well-ventilated area for radioactive materials. Users must adhere to all local and national regulations for the handling and disposal of radioactive substances.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (Radio-HPLC)	≥ 95%
Specific Activity	10-30 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (9:1) or as specified
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.