Description

2-Chloro-4-Trifluoromethylbenzoic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, combining a carboxylic acid group with chloro and trifluoromethyl substituents, makes it a critical intermediate for creating molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated benzoic acid core to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Synthesis Building Block: Employed in coupling reactions (e.g., Suzuki, amidation) to introduce the 2-chloro-4-(trifluoromethyl)phenyl moiety into more complex molecular architectures.
• Polymer Modification: Can be used to synthesize monomers or additives for specialty polymers, imparting specific chemical resistance or surface properties.

Basic Information

Product Name	2-Chloro-4-Trifluoromethylbenzoic Acid
CAS No.	23228-45-7
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-toluic acid; 4-(Trifluoromethyl)-2-chlorobenzoic acid; 2-Chloro-4-(trifluoromethyl)benzoic acid; Benzoic acid, 2-chloro-4-(trifluoromethyl)-; 2-Chloro-α,α,α-trifluoro-4-methylbenzoic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Trifluoromethylbenzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets precise customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.