Description

Guanine-8-14C Hydrochloride is a stable isotope-labeled derivative of the nucleobase guanine, specifically radiolabeled with carbon-14 at the 8-position. This compound is an essential tool for researchers requiring precise metabolic and pharmacokinetic tracing in biochemical and pharmaceutical studies. It is primarily utilized in the development and analysis of nucleic acid analogs, antiviral agents, and for investigating purine metabolism pathways.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis, catabolism, and incorporation of guanine and related purines in in vitro and in vivo systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for the radiolabeled synthesis of drug candidates, enabling definitive ADME (Absorption, Distribution, Metabolism, Excretion) studies for regulatory submissions.
• Nucleic Acid Research: Serves as a building block for synthesizing radiolabeled oligonucleotides to probe nucleic acid structure, function, and protein-nucleic acid interactions.
• Biochemical Assay Development: Employed in the development of enzymatic assays for purine-metabolizing enzymes such as guanine deaminase and purine nucleoside phosphorylase.
• Antiviral and Anticancer Agent Research: Used in the synthesis and mechanistic study of labeled analogs targeting viral replication or cellular proliferation.
• Environmental and Agricultural Science: Applied in tracing the environmental fate and metabolic pathways of purine-based compounds in ecological systems.

Basic Information

Product Name	Guanine-8-14C Hydrochloride
CAS No.	23199-24-8
Molecular Formula	C514CH6N5O • HCl
Molecular Weight	~207.6 g/mol (for 14C-labeled form)
Synonyms	2-Amino-1,7-dihydro-6H-purin-6-one-8-14C hydrochloride; 2-Aminohypoxanthine-8-14C hydrochloride; Guanin-8-14C hydrochloride; [8-14C]Guanine hydrochloride; 6H-Purin-6-one, 2-amino-1,7-dihydro-, 8-14C-labeled, hydrochloride; 8-14C-Guanine HCl
EINECS	Contact for details

Quality Control

Every batch of Guanine-8-14C Hydrochloride is manufactured and analyzed under strict quality control protocols to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and analytical methods (e.g., HPLC, NMR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solubility	Soluble in dilute alkali, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.