Description

Lofepramine is a tricyclic antidepressant (TCA) compound with the CAS registry number 23047-25-8. It is valued in the pharmaceutical industry for its role as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and for research into neurochemical mechanisms. This compound is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of antidepressant APIs.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Biochemical Research: Used in neuroscience and pharmacology studies to investigate the mechanisms of tricyclic antidepressants.
• Process Development: Employed in R&D for optimizing synthetic routes and scaling up production of related therapeutic compounds.
• Custom Synthesis: Basis for the preparation of novel derivatives and analogs for drug discovery programs.

Basic Information

Product Name	Lofepramine
CAS No.	23047-25-8
Molecular Formula	C₂₆H₂₆ClN₃O
Molecular Weight	431.96 g/mol
Synonyms	Lofepramine; 4'-[3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-4-chloro-2-(methylamino)butyrophenone; Gamanil; Emdalen; Tymelyt; 23047-25-8; Lofepramine base; N-Methyl-4-chloro-γ-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-γ-oxobenzenebutanamine
EINECS	Contact for details

Quality Control

Our Lofepramine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality documentation, including Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data. The product meets specifications suitable for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.