Description

1β,3β,5,14-Tetrahydroxy-19-Oxo-5β-Bufa-20,22-Dienolide is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers requiring a reliable and consistent supply of advanced synthetic building blocks.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel cardioactive drugs and other therapeutic agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related bufadienolide compounds.
• Biochemical Studies: Employed in pharmacological research to investigate structure-activity relationships (SAR) and mechanisms of action related to Na+/K+-ATPase inhibition.
• Fine Chemical Synthesis: Acts as a sophisticated starting material or intermediate for the custom synthesis of complex natural product analogs and derivatives.

Basic Information

Product Name	1β,3β,5,14-Tetrahydroxy-19-Oxo-5β-Bufa-20,22-Dienolide
CAS No.	23044-69-1
Molecular Formula	C₂₄H₃₂O₇
Molecular Weight	432.51 g/mol
Synonyms	19-Oxobufalin; 19-Oxo-bufalin; 1β,3β,5,14-Tetrahydroxy-19-oxo-5β,20(22)-bufadienolide; Bufa-20,22-dienolide, 1β,3β,5,14-tetrahydroxy-19-oxo-5β-; 19-Oxobufa-20,22-dienolide; 5β-Bufa-20,22-dienolide, 1β,3β,5,14-tetrahydroxy-19-oxo-
EINECS	Contact for details

Quality Control

Our 1β,3β,5,14-Tetrahydroxy-19-Oxo-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR). We provide full traceability and a Certificate of Analysis (COA) is supplied with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.