Description

(+/-)-Nicotine CAS NO 22083-74-5 is a high-purity synthetic alkaloid, serving as a critical reference standard and active ingredient across multiple industries. Its consistent quality and defined chemical profile are essential for ensuring the accuracy of analytical methods and the efficacy of formulated products. This material is primarily required by manufacturers and research institutions in the pharmaceutical, agrochemical, and analytical chemistry sectors.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical instruments (HPLC, GC-MS) in drug testing and quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of nicotine-based therapeutics, such as nicotine replacement therapies (NRTs) like gums, patches, and lozenges.
• Agrochemical Research: Employed as a biochemical tool in the study and development of novel insecticides and pesticides, leveraging its action on the nicotinic acetylcholine receptor.
• Chemical Synthesis: Acts as a versatile chiral precursor or intermediate in organic synthesis for more complex alkaloids and specialty chemicals.
• Biochemical & Neurological Research: Utilized in in-vitro and in-vivo studies to investigate nicotinic receptor function, addiction mechanisms, and related neurological pathways.
• Analytical Chemistry: Functions as a critical component in method development and proficiency testing for forensic and toxicology laboratories.

Basic Information

Item	Details
Product Name	(+/-)-Nicotine
CAS No.	22083-74-5
Molecular Formula	C10H14N2
Molecular Weight	162.23 g/mol
Synonyms	Nicotine (racemic); DL-Nicotine; 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine (racemate); (RS)-Nicotine; β-Pyridyl-α-N-methylpyrrolidine; 1-Methyl-2-(3-pyridyl)pyrrolidine; Nicotine USP; Nicotine base
EINECS	244-738-4

Quality Control

Our (+/-)-Nicotine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay, identification, and impurity profiling via HPLC and GC, to ensure it meets stringent specifications for pharmaceutical and research use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from strong alkalis and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow oily liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Specific Rotation	N/A (racemic mixture)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.