Description

Glycine, [2-3H] is a high-specific-activity tritium-labeled derivative of the fundamental amino acid glycine. This labeled compound is essential for advanced research requiring precise metabolic and biochemical pathway tracing. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) engaged in autoradiography, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and receptor binding assays.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer in studies of amino acid metabolism, protein synthesis, and neurotransmitter function.
• Drug Discovery & Development: Critical for autoradiography and quantitative whole-body autoradiography (QWBA) in preclinical ADME studies to determine the distribution of drug candidates.
• Biochemical Research: Employed in receptor-ligand binding assays and enzyme studies where a labeled glycine moiety is required.
• Nutritional Science Research: Facilitates the study of glycine uptake, utilization, and turnover in various biological systems and model organisms.
• Quality Control Reference Standard: Serves as a critical reference material in analytical laboratories for method development and validation in radiochemical analysis.

Basic Information

Product Name	Glycine, [2-3H]
CAS No.	21931-03-3
Molecular Formula	C₂H₃TNO₂
Molecular Weight	~76.06 g/mol (exact mass depends on specific activity)
Synonyms	Tritiated Glycine; [2-³H]Glycine; Glycine-2-t; Aminoacetic acid-2-t; 2-Tritioglycine; Glycine (tritiated); H-Gly-OH (2-³H); NSC 20258 (labeled)
EINECS	Contact for details

Quality Control

Every batch of Glycine, [2-3H] is manufactured and analyzed under strict quality systems to ensure radiochemical purity and specific activity meet the stringent requirements of research applications. Comprehensive analysis is performed using techniques including HPLC with radiometric detection. A detailed Certificate of Analysis (COA), specifying batch-specific radioactivity, purity, and solvent composition, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be kept in sealed vials under inert atmosphere to minimize radiolytic decomposition and maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (in specified solvent)
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC-UV)	≥ 98%
Solvent	Ethanol:Water or as specified
Concentration	1 mCi/mL (as specified per batch)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.