Description

Glutamic Acid, L-, [3H(G)] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Glutamic acid, identified by CAS NO 21675-62-7. This radiolabeled compound is a critical tool for researchers requiring precise metabolic and biochemical pathway tracing. It is indispensable for scientists in pharmaceutical development, neurochemistry, and metabolic research who need to study glutamate receptor binding, amino acid transport, and protein synthesis with high sensitivity.

Application

• Biochemical Research & Tracer Studies: Used as a radioactive tracer to investigate the metabolism, uptake, and transport mechanisms of glutamic acid in biological systems.
• Neuropharmacology & Receptor Binding Assays: Essential for studying the binding affinity and kinetics of ligands at glutamate receptors (e.g., NMDA, AMPA, kainate receptors).
• Drug Discovery & Development: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies for pharmaceuticals targeting the glutamatergic system.
• Metabolic Pathway Analysis: Tracks the incorporation of glutamic acid into proteins and other metabolites in cell culture and animal models.
• Enzymology Studies: Serves as a substrate for enzymes such as glutaminase and glutamate dehydrogenase in kinetic and mechanistic studies.
• Autoradiography & Imaging: Used in tissue section autoradiography to localize sites of glutamate activity and receptor distribution.

Basic Information

Product Name	Glutamic Acid, L-, [3H(G)]
CAS No.	21675-62-7
Molecular Formula	C5H9NO4 (³H labeled)
Molecular Weight	Contact for details (varies with specific activity)
Synonyms	L-Glutamic acid-3,4-³H; (S)-2-Aminopentanedioic acid-3,4-³H; Tritiated L-Glutamic Acid; [³H]L-Glutamic Acid; H-Glu-OH-³H; Glutamic Acid-³H; ³H-Glutamic Acid; L-Glutamate-³H
EINECS	Contact for details

Quality Control

Every batch of our tritium-labeled L-Glutamic Acid is manufactured and analyzed under strict quality systems to ensure radiochemical purity and specific activity meet exacting research standards. Comprehensive quality control includes verification by HPLC with radiometric detection. A detailed Certificate of Analysis (COA), specifying batch-specific radioactivity, purity, and solvent composition, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to minimize radiolytic decomposition. Always handle in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless solution
Specific Activity	20-60 Ci/mmol (Contact for specific batch data)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL (Contact for other concentrations)
Solvent	Aqueous ethanol solution
Identification (HPLC, MS)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.