Description

Mianserin Hydrochloride CAS NO 21535-47-7 is a high-purity pharmaceutical active ingredient belonging to the tetracyclic antidepressant class. It is a critical intermediate and reference standard in the research, development, and quality control of neuropharmacological agents. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on central nervous system (CNS) therapeutics and metabolite studies.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of antidepressant medications.
• Reference Standard: Serves as a certified standard for quality control (QC) and quality assurance (QA) in pharmaceutical manufacturing.
• Research & Development: Used in preclinical and clinical studies investigating the pharmacology of tetracyclic antidepressants.
• Metabolite Synthesis: Acts as a precursor in the synthesis of key metabolites for pharmacokinetic and toxicological studies.
• Analytical Testing: Employed in method development and validation for HPLC, LC-MS, and other analytical techniques.
• Academic Research: Utilized in university and institutional research on serotonin receptors and neurotransmitter systems.

Basic Information

Product Name	Mianserin Hydrochloride
CAS No.	21535-47-7
Molecular Formula	C₁₈H₂₀N₂·HCl
Molecular Weight	300.83 g/mol
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine monohydrochloride; Mianserin HCl; Tolvin; Tolvon; Bolvidon; Norval; Organon Brand of Mianserin Hydrochloride; 6H-Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride
EINECS	244-440-6

Quality Control

Our Mianserin Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with ICH guidelines and current Good Manufacturing Practice (cGMP) principles for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.