Description

Cyclohexanecarboxylic Acid, 3-Hydroxy-, (1R,3S)- is a high-purity, single-isomer chiral building block of significant importance in advanced organic synthesis. This compound, with CAS number 21531-44-2, is valued for its defined stereochemistry and functional groups, which enable precise molecular construction. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and complex specialty molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure drugs, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric excess.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in homogeneous catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex agrochemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable compound for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 3-Hydroxy-, (1R,3S)-
CAS No.	21531-44-2
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(1R,3S)-3-Hydroxycyclohexanecarboxylic acid; (1R,3S)-3-Hydroxy-1-cyclohexanecarboxylic acid; (-)-cis-3-Hydroxycyclohexanecarboxylic acid; (1R,3S)-HCCA; cis-(-)-3-Hydroxycyclohexanecarboxylic acid; (1R,3S)-3-HCCA; L-erythro-3-Hydroxycyclohexanecarboxylic acid (specific stereoisomer)
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 3-Hydroxy-, (1R,3S)- is manufactured under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and stereochemical integrity, with typical purity levels exceeding 98% (by HPLC). A comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), assay, and impurity profile is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.