Description

(S)-(+)-Methyl Mandelate CAS NO 21210-43-5 is a high-purity chiral building block and resolving agent of significant importance in asymmetric synthesis. Its value lies in its utility for the preparation of enantiomerically pure pharmaceuticals, agrochemicals, and fine chemicals. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable source of a specific enantiomer for chiral synthesis and resolution processes.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the production of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system drugs.
• Chiral Resolving Agent: Used to separate racemic mixtures of acids and amines via diastereomeric salt formation, a critical step in purifying single enantiomers.
• Agrochemical Intermediate: Employed in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantioselective.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis, such as hydrogenation and alkylation reactions.
• Fine Chemical and Flavor/Fragrance Synthesis: Used in the production of high-value chiral compounds for flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new asymmetric synthetic routes in laboratory settings.

Basic Information

Product Name	(S)-(+)-Methyl Mandelate
CAS No.	21210-43-5
Molecular Formula	C9H10O3
Molecular Weight	166.17 g/mol
Synonyms	(S)-(+)-Methyl 2-Hydroxy-2-phenylacetate; (S)-Methyl Mandelate; L-Methyl Mandelate; Methyl (S)-(+)-Mandelate; (S)-2-Hydroxy-2-phenylacetic acid methyl ester; (+)-Methyl Mandelate; (S)-α-Hydroxybenzeneacetic acid methyl ester; Mandelic acid methyl ester, (S)-
EINECS	244-263-3

Quality Control

Our (S)-(+)-Methyl Mandelate is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR, and purity assessment. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	53 - 57 °C
Specific Rotation [α]20/D	+140° to +150° (c=1 in methanol)
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.