Description

Aminobutyric Acid, Gamma, [4-14C] CAS NO 21195-45-9 is a carbon-14 labeled isotopologue of the essential neurotransmitter γ-aminobutyric acid (GABA). This radiolabeled compound is a critical tool for tracing metabolic pathways, studying receptor binding, and investigating the pharmacokinetics of GABAergic systems in vivo and in vitro. It is indispensable for researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors who require precise, high-specific-activity tracers for advanced analytical studies.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of GABA and related compounds.
• Neuropharmacology Research: Essential for autoradiography, receptor binding assays, and uptake studies to elucidate the function of GABA receptors and transporters.
• Biochemical Pathway Analysis: Tracks the incorporation of GABA into the citric acid cycle (succinate pathway) and other metabolic routes in plant and animal systems.
• Agrochemical Research: Employed in studies to understand the mode of action and environmental fate of pesticides that affect the GABA system in pests.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive LC-MS/MS or radio-HPLC methods.
• Quality Control for Radiopharmaceuticals: Used in the synthesis and purity assessment of carbon-14 labeled drug candidates targeting the central nervous system.

Basic Information

Product Name	Aminobutyric Acid, Gamma, [4-14C]
CAS No.	21195-45-9
Molecular Formula	C₄H₉¹⁴CNO₂
Molecular Weight	~105.1 g/mol (exact mass depends on specific activity)
Synonyms	4-Aminobutyric-4-14C acid; GABA-[4-14C]; γ-Aminobutyric-4-14C acid; Piperidinic-4-14C acid; 4-Amino[4-14C]butanoic acid; [4-14C]-GABA; (4-14C)-Aminobutyric Acid
EINECS	Contact for details

Quality Control

Every batch of our [4-14C]-GABA is manufactured and analyzed under strict quality systems to ensure traceability and reliability for your critical research. We provide comprehensive Certificates of Analysis (COA) that detail radiochemical purity (typically >97% by radio-HPLC), specific activity, chemical purity, and solvent composition. Our quality commitment aligns with the standards expected for research chemicals in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. Solutions should be prepared in appropriate buffers and used immediately or stored according to the specific stability of the formulation. Always adhere to local regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR/NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol/Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.