Description

(R)-(-)-Methyl Mandelate CAS NO 20698-91-3 is a high-purity chiral building block and intermediate of significant value in asymmetric synthesis. This optically active ester is crucial for the production of enantiomerically pure pharmaceuticals and fine chemicals, where stereochemical integrity directly impacts efficacy and safety. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiopure drugs, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used to prepare chiral ligands for transition metal catalysts employed in stereoselective reactions like hydrogenation and cross-coupling.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and pesticides with improved selectivity.
• Flavor and Fragrance Industry: Employed in the synthesis of chiral aroma chemicals and flavor compounds where specific stereoisomers define the sensory profile.
• Academic and R&D: A valuable reagent in methodological development for new asymmetric transformations and stereochemistry studies.
• Resolution Agent: Can be utilized in the chiral resolution of racemic mixtures via diastereomeric salt formation or derivative synthesis.

Basic Information

Product Name	(R)-(-)-Methyl Mandelate
CAS No.	20698-91-3
Molecular Formula	C9H10O3
Molecular Weight	166.17 g/mol
Synonyms	(R)-(-)-Methyl 2-Hydroxy-2-phenylacetate; (R)-Methyl Mandelate; (R)-Mandelic Acid Methyl Ester; (-)-Methyl Mandelate; Methyl (R)-(-)-Mandelate; (2R)-2-Hydroxy-2-phenylacetic acid methyl ester; (R)-α-Hydroxybenzeneacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-(-)-Methyl Mandelate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	52 - 56 °C
Specific Rotation [α]20/D	-130° to -140° (c=1 in methanol)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.