Description

α-Fluorocinnamic Acid is a high-value fluorinated aromatic building block characterized by its cinnamic acid backbone with a fluorine substituent on the alpha carbon. This unique structure makes it a versatile intermediate for synthesizing more complex fluorinated compounds, where the fluorine atom can significantly alter electronic properties, metabolic stability, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, crop protection, and organic electronics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to enhance drug-like properties.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorine atom improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Peptide Mimetics & Bio-conjugation: Employed in the design of fluorinated amino acid analogs and as a linker in bioconjugation chemistry for probes and diagnostics.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to construct complex, fluorinated biaryl systems.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and fluorine chemistry research.

Basic Information

Product Name	α-Fluorocinnamic Acid
CAS No.	20397-61-9
Molecular Formula	C9H7FO2
Molecular Weight	166.15 g/mol
Synonyms	(E)-3-Fluoro-3-phenylacrylic acid; 3-Fluoro-3-phenylpropenoic acid; 2-Fluorocinnamic acid; α-Fluorocinnamic acid; trans-α-Fluorocinnamic acid; (E)-α-Fluorocinnamic acid; 3-Fluoroacrylic acid, 3-phenyl-; NSC 33436
EINECS	243-803-4

Quality Control

Every batch of α-Fluorocinnamic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO-guided environments for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.