Description

9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)Adenine is a high-purity fluorinated nucleoside analog, a critical building block in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of antiviral and anticancer therapeutics, where its specific stereochemistry and fluorine substitution are essential for biological activity. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of antiviral agents, particularly for compounds targeting viral polymerases.
• Anticancer Drug Development: Serves as a building block for investigational nucleoside analogs designed to inhibit cancer cell proliferation.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Pro-drug Synthesis: Employed in the chemical modification and development of pro-drug forms to enhance bioavailability and therapeutic efficacy.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Reference Standard: Utilized as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)Adenine
CAS No.	20227-41-2
Molecular Formula	C15H18FN5O4
Molecular Weight	351.34 g/mol
Synonyms	2'-Fluoro-2'-deoxy-β-D-arabinofuranosyladenine; 2'-F-β-D-Ara-A; 2'-F-Ara-A; 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine; 2'-Fluoro-ara-Adenine; β-2'-Fluoro-2'-deoxyarabinofuranosyladenine; 2'-F-2'-deoxy-β-D-arabinofuranosyladenine; Fludarabine intermediate
EINECS	Contact for details

Quality Control

Our 9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)Adenine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and MS for comprehensive characterization and purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.