Description

L-Lysine-(4 5-3H(N)) CAS NO 20166-34-1 is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Lysine, serving as a critical tool in biochemical and pharmacological research. This radiolabeled compound is indispensable for conducting precise tracer studies, enabling researchers to investigate metabolic pathways, protein synthesis, and cellular uptake mechanisms with high sensitivity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on drug discovery, nutrition science, and molecular biology.

Application

• Metabolic Pathway Tracing: Used as a radioactive tracer to study lysine metabolism, protein turnover, and amino acid utilization in vivo and in vitro.
• Drug Discovery & Pharmacokinetics (PK/PD): Essential for labeling candidate drug molecules to track absorption, distribution, metabolism, and excretion (ADME) profiles.
• Biomedical Research: Enables autoradiography and binding assays to study receptor-ligand interactions and cellular transport mechanisms.
• Nutritional Science Studies: Facilitates research on amino acid requirements, bioavailability, and the impact of dietary lysine in animal and human models.
• Protein Synthesis & Degradation Analysis: Employed to measure rates of protein synthesis and degradation in various tissues and cell cultures.
• Quality Control Reference Standard: Acts as a reference material in analytical method development and validation for lysine quantification.

Basic Information

Product Name	L-Lysine-(4 5-3H(N))
CAS No.	20166-34-1
Molecular Formula	C6H143H2N2O2 * (HCl)
Molecular Weight	Contact for details
Synonyms	(2S)-2,6-Diamino-4,5-tritiohexanoic acid; L-Lysine-4,5-t; Tritiated L-Lysine; L-Lysine, 4,5-tritiated; [4,5-3H]-L-Lysine; Lysine-(4,5-3H); H-Lys-OH-4,5-3H; (S)-2,6-Diamino-[4,5-3H]hexanoic acid
EINECS	Contact for details

Quality Control

Every batch of L-Lysine-(4 5-3H(N)) is manufactured and controlled under a strict quality management system. The product undergoes rigorous analytical testing, including radiochemical purity determination by HPLC and specific activity verification, to ensure it meets the exacting standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA), detailing purity, specific activity, and solvent composition, is provided with each shipment to guarantee traceability and reproducibility in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as supplied. Due to its highly volatile nature (tritium), appropriate containment and laboratory practices for handling radioactive materials must be strictly followed. Store in a dedicated, well-ventilated area designated for radiochemicals.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	20-80 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water (Specified ratio, see COA)
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.