Description

Prostaglandin E1-[5,6-3H(N)] is a tritium-labeled analog of the key bioactive lipid mediator, Prostaglandin E1 (Alprostadil). This high-specific-activity radioligand is essential for advanced pharmacological and biochemical research, enabling precise tracking and quantification in complex biological systems. It is primarily utilized by research scientists and pharmaceutical developers in the fields of cardiovascular research, inflammation studies, and receptor binding assays.

Application

• Receptor Binding and Pharmacological Assays: Used as a high-affinity tracer to study prostaglandin EP receptor subtypes, their distribution, and ligand interactions.
• Metabolic Pathway Tracing: Enables detailed investigation of the arachidonic acid cascade, PGE1 metabolism, and eicosanoid signaling pathways.
• Drug Discovery & Development: Critical for screening and characterizing novel compounds targeting prostaglandin pathways for cardiovascular, anti-inflammatory, or erectile dysfunction therapies.
• Autoradiography & Imaging Studies: Facilitates the spatial visualization of receptor localization in tissue sections for disease mechanism research.
• In Vitro Diagnostic (IVD) Development: Serves as a key component in the development of sensitive radioimmunoassays (RIA) for prostaglandin quantification.
• Vascular and Smooth Muscle Research: Applied in studies examining vasodilation, platelet aggregation inhibition, and vascular smooth muscle cell proliferation.

Basic Information

Product Name	Prostaglandin E1-[5,6-3H(N)]
CAS No.	20045-36-7
Molecular Formula	C20H34O5 (with tritium label at positions 5,6)
Molecular Weight	~354.5 g/mol (unlabeled)
Synonyms	Alprostadil-[5,6-3H]; [5,6-3H]PGE1; Tritiated Prostaglandin E1; 11α,15(S)-Dihydroxy-9-oxoprosta-13-en-1-oic acid-[5,6-3H(N)]; PGE1-[5,6-3H(N)]; Prostaglandin E1 (tritiated); 3H-PGE1
EINECS	Contact for details

Quality Control

Every batch of Prostaglandin E1-[5,6-3H(N)] is manufactured and analyzed under strict quality systems. Radiochemical purity and specific activity are determined using validated methods such as HPLC with radiometric detection. Certificates of Analysis (COA) are provided, detailing specific activity (Ci/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent specifications. Our quality commitment ensures reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. Due to its highly volatile nature (tritium label), appropriate laboratory containment and handling procedures for radioactive materials must be followed at all times. For long-term stability, avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	30-100 Ci/mmol (1.11-3.7 TBq/mmol) [Custom ranges available]
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol or Ethanol:Water mixture
Concentration	1.0 mCi/mL (37 MBq/mL) [Custom concentrations available]

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.