Description

Nicotinic Acid-Carboxy-14C is a carbon-14 labeled isotopologue of nicotinic acid (vitamin B3), specifically radiolabeled at the carboxylic acid carbon position. This compound is an essential tool for conducting advanced metabolic and pharmacokinetic studies, enabling precise tracking of the vitamin's fate in biological systems. It is primarily required by research institutions, pharmaceutical R&D departments, and agrochemical companies engaged in tracer studies, drug metabolism research, and biochemical pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of nicotinic acid and related drug candidates.
• Biochemical Pathway Analysis: Essential for elucidating the metabolic pathways of vitamin B3, including its role in NAD/NADP cofactor biosynthesis and other cellular processes.
• Agricultural Chemical Research: Employed in studies to understand the uptake, translocation, and metabolic fate of nicotinate-based compounds in plants and soil.
• Nutritional Science Research: Facilitates precise studies on the bioavailability, tissue distribution, and turnover of vitamin B3 in animal and human models.
• Analytical Method Development: Serves as a critical internal standard or reference material in the development and validation of sensitive LC-MS/MS or radio-HPLC methods.
• Environmental Fate Studies: Applied in research to track the environmental degradation and persistence of nicotinic acid derivatives.

Basic Information

Product Name	Nicotinic Acid-Carboxy-14C
CAS No.	2906-42-5
Molecular Formula	C6H414CNO2
Molecular Weight	~124.11 g/mol (exact mass depends on 14C enrichment)
Synonyms	3-Pyridinecarboxylic-14C acid
Vitamin B3-14C (carboxy labeled)
Niacin-14C (carboxy labeled)
Pyridine-3-carboxylic-1-14C acid
[Carboxy-14C]Nicotinic Acid
3-Carboxy-14C-pyridine
Nicotinic Acid (carboxyl-14C)
EINECS	220-823-1 (for the unlabeled compound)

Quality Control

Every batch of Nicotinic Acid-Carboxy-14C is manufactured and handled under strict quality protocols to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for research. Our products undergo rigorous analytical testing, including HPLC and radio-HPLC. Certificates of Analysis (COA) detailing batch-specific data on purity, activity, and solvent composition are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures of 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment to maintain stability and prevent decomposition. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solutions)	As specified (e.g., Ethanol, Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.