Description

Acetic Acid, [1-14C] CAS NO 2845-03-6 is a carbon-14 labeled isotopologue of acetic acid, where the radioactive isotope carbon-14 is specifically incorporated at the carboxyl carbon position. This product is essential for precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of acetic acid and its derivatives in complex biological and chemical systems. It is a critical reagent for scientists in pharmaceutical research, biochemistry, and environmental science who require high-specific-activity tracers for advanced analytical techniques.

Application

• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the biochemical pathways of acetate in cells, tissues, and whole organisms.

• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled precursor or intermediate in the synthesis of labeled drug candidates for absorption, distribution, metabolism, and excretion (ADME) studies.

• Biochemical Research: Employed in enzyme mechanism studies, particularly for acetyltransferases and other enzymes utilizing acetyl-CoA as a substrate.

• Environmental Fate Studies: Applied to track the degradation and transformation of acetic acid and related compounds in environmental samples.

• Radiochemical Synthesis: Acts as a key building block for the preparation of other carbon-14 labeled compounds with high specific activity.

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  | Product Name | Acetic Acid, [1-14C] |
  | CAS No. | 2845-03-6 |
  | Molecular Formula | C14CH4O2 / C2H4O2 (¹⁴C labeled) |
  | Molecular Weight | ~61.05 g/mol (varies with specific activity) |
  | Synonyms | Acetic-1-¹⁴C Acid; [1-¹⁴C]Acetic Acid; Carbon-14 Labeled Acetic Acid; Ethanoic-1-¹⁴C Acid; [Carboxy-¹⁴C]Acetic Acid; Radioactive Acetic Acid; CH3¹⁴COOH; Isotopic Acetic Acid |
  | EINECS | 220-646-8 (for unlabeled acetic acid) |

  Quality Control

  Every batch of Acetic Acid, [1-14C] is manufactured and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, specific activity, and radiochemical stability. Our products undergo rigorous testing to ensure compliance with industry standards. Comprehensive Certificates of Analysis (COA) detailing purity, specific activity, solvent composition, and analytical methods (HPLC, TLC, NMR) are provided with each shipment.

  Storage

  Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. Due to its nature as a strong acid/organic solvent and highly volatile compound, ensure adequate ventilation in storage areas and keep away from incompatible materials such as strong oxidizers and bases.

  Specification

  Item	Specification
  Appearance	Clear, Colorless Solution
  Identification (IR/NMR)	Conforms to Structure
  Radiochemical Purity (HPLC/TLC)	≥ 98%
  Chemical Purity (HPLC/GC)	≥ 98%
  Specific Activity	50-60 mCi/mmol (Contact for specific batch data)
  Solvent	Water or as specified
  Concentration	1.0 mCi/mL (or as customized)

  Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.**