Description

[[(2R,3S,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid CAS NO 2793-06-8 is a high-purity nucleotide analog, specifically the active triphosphate form of the antiviral agent Tenofovir. This compound is critical for research and development in antiviral therapies, serving as the direct intracellular metabolite responsible for inhibiting viral replication. It is an essential building block for pharmaceutical companies, diagnostic manufacturers, and advanced research institutions focused on virology, enzymology, and nucleoside chemistry.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key synthetic precursor in the manufacture of Tenofovir Disoproxil Fumarate and related prodrugs.
• Antiviral Research & Development: Used as a reference standard and biochemical tool in studies targeting HIV-1, HBV, and other viral polymerases (reverse transcriptase).
• Enzymology Studies: Serves as a substrate for kinetic assays and mechanistic studies of viral and cellular polymerases and kinases.
• Diagnostic Kit Development: Employed in the formulation of assays and kits for antiviral drug resistance testing and viral load monitoring.
• Nucleic Acid Chemistry: Used in the synthesis of modified oligonucleotides for probing biological mechanisms and developing novel therapeutics.
• Process Development & Validation: Critical for scaling up synthesis, optimizing manufacturing processes, and ensuring regulatory compliance in drug production.

Basic Information

Product Name	[[(2R,3S,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid
CAS No.	2793-06-8
Molecular Formula	C9H14N5O10P3
Molecular Weight	469.15 g/mol
Synonyms	Tenofovir Triphosphate; (R)-PMPA Triphosphate; (R)-9-[2-(Phosphonomethoxy)propyl]adenine Triphosphate; GS-1278 Triphosphate; TAF Intermediate; PMPA Triphosphate; (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl (hydroxyphosphonooxy)phosphoryl hydrogen phosphate
EINECS	Contact for details

Quality Control

Our [[(2R,3S,5R)-5-(6-Aminopurin-9-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation and NMR for structural verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.