Description

(R)-(+)-Thalidomide CAS NO 2614-06-4 is the single enantiomer of the thalidomide molecule, a compound of significant historical and contemporary scientific interest. This specific stereoisomer is a critical chiral building block and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology, immunology, and targeted protein degradation studies. The compound's role is essential for investigating structure-activity relationships and developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in API manufacturing.
• Chiral Intermediate: Used in the asymmetric synthesis of novel drug candidates, particularly in oncology and immunomodulatory therapies.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate mechanisms of action related to anti-angiogenesis and immunomodulation.
• PROTAC & Molecular Glue Development: Acts as a key ligand or starting material in the design of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation.
• Academic Research: Utilized in university and institutional labs for pharmacological and toxicological studies.
• Regulatory & Compliance Testing: Applied in testing laboratories to ensure the enantiomeric purity of pharmaceutical products and raw materials.

Basic Information

Product Name	(R)-(+)-Thalidomide
CAS No.	2614-06-4
Molecular Formula	C13H10N2O4
Molecular Weight	258.23 g/mol
Synonyms	(R)-Thalidomide; (+)-Thalidomide; (R)-(+)-2-(2,6-Dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; D-Thalidomide; (R)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; (3R)-2-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; α-Phthalimidoglutarimide (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-(+)-Thalidomide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure high chemical and optical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request. We support compliance with cGMP and ICH guidelines for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.