Description

Boc-Glu Anhydride CAS NO 2420-13-5 is a high-purity, protected amino acid derivative widely used as a critical building block in organic synthesis. Its primary value lies in enabling the controlled, sequential construction of complex peptides and other bioactive molecules by providing a reactive anhydride group while protecting the α-amino functionality. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in peptide synthesis and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the efficient incorporation of glutamic acid into peptide chains under mild conditions.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides, peptidomimetics, and peptide conjugates in solution.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Bioconjugation and Labeling: Facilitates the attachment of peptides or glutamic acid residues to other molecules, such as proteins, polymers, or fluorescent dyes.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides orthogonal protection, allowing for selective deprotection in multi-step syntheses.
• Research & Development: A standard reagent in academic and industrial R&D labs for exploring new synthetic methodologies and novel bioactive compounds.

Basic Information

Product Name	Boc-Glu Anhydride
CAS No.	2420-13-5
Molecular Formula	C10H15NO5
Molecular Weight	229.23 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutamic Anhydride; Boc-L-Glutamic Acid Anhydride; (S)-5-((tert-Butoxycarbonyl)amino)-5-oxopentanoic Anhydride; N-Boc-L-glutamic Anhydride; Boc-Glu-OAn; 1-((S)-5-Oxooxolan-2-yl)-2-methylpropan-2-yl Carbamate; N-tert-Butoxycarbonyl-L-glutamic Acid Cyclic Anhydride; N-Boc-glutamic anhydride
EINECS	219-347-8

Quality Control

Our Boc-Glu Anhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.