Description

2-Chloro-4-Fluorobenzoic Acid is a versatile halogenated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the carboxylic acid group and the strategically positioned halogen atoms enable precise chemical modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated and chlorinated aromatic core.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the halogenated structure contributes to biological activity and stability.
• Liquid Crystal Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystals used in display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, functionalized molecules.
• Polymer Modifier: Can be incorporated into polymer chains to alter physical properties such as thermal stability and solubility.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new chemical spaces and reaction pathways.

Basic Information

Product Name	2-Chloro-4-Fluorobenzoic Acid
CAS No.	2252-51-9
Molecular Formula	C7H4ClFO2
Molecular Weight	174.56 g/mol
Synonyms	2-Chloro-4-fluorobenzoic acid; 4-Fluoro-2-chlorobenzoic acid; Benzoic acid, 2-chloro-4-fluoro-; 2-Chloro-4-fluorobenzenecarboxylic acid; NSC 403121; 2252-51-9; o-Chloro-p-fluorobenzoic acid
EINECS	218-838-6

Quality Control

Our 2-Chloro-4-Fluorobenzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for synthesis and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	162 - 166 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.