Description

L-Menthylamine is a chiral amine derivative of menthol, characterized by its distinct minty, camphoraceous odor. This versatile chiral building block is crucial for the synthesis of high-value compounds in the pharmaceutical and flavor & fragrance industries, where its stereochemistry imparts specific biological activity or sensory properties. It is primarily sought after by R&D chemists and process development teams for applications in asymmetric synthesis, agrochemicals, and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of local anesthetics, antitussives, and other therapeutic agents.
• Flavor and Fragrance Ingredient: Used in the creation and modification of minty, cooling, or camphoraceous notes in perfumes, cosmetics, and food flavorings.
• Agrochemical Synthesis: Serves as a precursor in the manufacturing of certain pesticides and herbicides, leveraging its chiral structure for targeted biological activity.
• Catalyst and Ligand Preparation: Employed in the development of chiral catalysts and ligands for asymmetric hydrogenation and other enantioselective reactions.
• Organic Synthesis Building Block: Utilized in research and fine chemical production for the introduction of the bulky, chiral menthyl group to control stereochemistry.
• Resolution Agent: Acts as a chiral resolving agent for the separation of racemic mixtures of carboxylic acids via diastereomeric salt formation.

Basic Information

Product Name	L-Menthylamine
CAS No.	2216-54-8
Molecular Formula	C10H21N
Molecular Weight	155.28 g/mol
Synonyms	(-)-Menthylamine; L-(-)-Menthylamine; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanamine; (1R)-2-Isopropyl-5-methylcyclohexanamine; L-Menthanamine; (-)-1-Methyl-4-isopropylcyclohexylamine; p-Menth-1-ylamine; (1R,2S,5R)-Menthylamine
EINECS	218-713-7

Quality Control

Our L-Menthylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by GC or HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and specific impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at room temperature for shorter periods. The container should be kept tightly sealed to prevent moisture absorption and oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Specific Rotation [α]20/D	-25° to -30° (c=1 in Ethanol)
Refractive Index n20/D	1.465 - 1.475
Density (20°C)	0.890 - 0.910 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.