Description

Imipramine n-Oxide is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant imipramine. This compound is essential for advanced research and development in neuropharmacology and drug metabolism studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and analytical method development.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis and research of tricyclic antidepressant compounds and related analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical laboratories for pharmacokinetic and drug metabolism studies.
• Biochemical Research: Employed in neuroscience research to study the metabolic pathways and mechanisms of action of psychotropic drugs.
• Analytical Chemistry: Serves as a high-purity standard for HPLC, LC-MS, and GC-MS methods in quality control and forensic analysis.
• API Development: Used in the development and scale-up processes for new chemical entities (NCEs) targeting the central nervous system.

Basic Information

Product Name	Imipramine n-Oxide
CAS No.	2207-85-4
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Imipramine N-Oxide; Imipramine Oxide; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine N-Oxide; Desipramine N-Oxide Precursor; N-Desmethylimipramine N-Oxide; Imipramine Metabolite; G-35259
EINECS	Contact for details

Quality Control

Our Imipramine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.