Description

L-Methionine, [Methyl-14C] is a radiolabeled form of the essential sulfur-containing amino acid L-Methionine, where the carbon-14 isotope is specifically incorporated into the methyl group. This compound is a crucial tracer in metabolic and biochemical research, enabling the precise tracking of methionine's incorporation into proteins and its role in methylation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) conducting advanced studies in drug metabolism, protein synthesis, and one-carbon cycle analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the metabolic fate of methionine-containing compounds and related drugs.
• Protein Synthesis and Turnover Research: Quantifying rates of protein synthesis and degradation in cell culture and animal models.
• Methylation Pathway Analysis: Investigating S-adenosylmethionine (SAMe) dependent methylation processes in epigenetics and signal transduction.
• Autoradiography and Imaging: Used in whole-body autoradiography (WBA) and micro-autoradiography for spatial localization studies.
• Biochemical Assay Development: Serving as a standard or tracer in enzymatic assays related to methionine metabolism.
• Nutritional and Metabolic Disorder Research: Studying methionine metabolism in models of liver disease, homocystinuria, and other metabolic conditions.

Basic Information

Product Name	L-Methionine, [Methyl-14C]
CAS No.	2105-18-2
Molecular Formula	C5H11NO2S * (14C)
Molecular Weight	~150.21 g/mol (with 14C)
Synonyms	(S)-2-Amino-4-((methyl-14C)methylthio)butyric acid; L-2-Amino-4-(methylthio)butyric acid (methyl-14C); Methionine (L-), methyl-14C; L-Methionine (methyl-14C); [14C]-L-Methionine; Radiolabeled L-Methionine; Carbon-14 labeled Methionine
EINECS	Contact for details

Quality Control

Every batch of L-Methionine, [Methyl-14C] is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure compliance with specifications for radiochemical purity, chemical purity, and specific activity. Certificates of Analysis (COA) are provided with each shipment, detailing results for assay, radiochemical purity (typically by HPLC), and specific activity. Our quality commitment supports research requiring reliable and consistent tracer materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, keep the material in its original packaging within a designated freezer. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR/HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Solvent (if supplied as solution)	Ethanol/Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.