Description

Methyl 2,6-Difluoro-4-(trifluoromethyl)benzoate is a high-value, multi-fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms and the trifluoromethyl group, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require precise fluorination to optimize lead compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and trifluoromethyl motifs contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to desired dielectric anisotropy, thermal stability, and luminescent properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex, fluorinated benzoate motifs into larger molecular architectures.
• Polymer & Specialty Chemicals: Acts as a monomer or modifier in the synthesis of high-performance polymers, coatings, and surfactants that require fluorine's unique hydrophobic and oleophobic characteristics.

Basic Information

Product Name	Methyl 2,6-Difluoro-4-(trifluoromethyl)benzoate
CAS No.	1980049-41-9
Molecular Formula	C9H5F5O2
Molecular Weight	240.13 g/mol
Synonyms	2,6-Difluoro-4-(trifluoromethyl)benzoic acid methyl ester; Methyl 2,6-difluoro-4-(trifluoromethyl)benzoate; Benzoic acid, 2,6-difluoro-4-(trifluoromethyl)-, methyl ester; Methyl α,α,α,2,6-pentafluorotoluate; 4-(Trifluoromethyl)-2,6-difluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2,6-Difluoro-4-(trifluoromethyl)benzoate adheres to a stringent quality management system. Every batch is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, impurity profile, and physical data are provided and available upon request, supporting your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.