Description

Danicamtiv CAS NO 1970972-74-7 is a potent and selective small molecule myosin activator, representing a significant advancement in cardiac pharmacology. This compound is crucial for research and development targeting the treatment of systolic heart failure by directly enhancing cardiac contractility. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and contract manufacturing organizations (CMOs) focused on next-generation cardiovascular therapeutics.

Application

• Cardiovascular Drug Discovery: A key investigational new drug (IND) candidate for the treatment of heart failure with reduced ejection fraction (HFrEF).
• Preclinical & Clinical Research: Used in in vitro and in vivo studies to elucidate the mechanism of cardiac myosin activation and its therapeutic potential.
• Pharmacology Reference Standard: Serves as a high-purity analytical standard for bioassay development, pharmacokinetic (PK), and pharmacodynamic (PD) studies.
• Formulation Development: Utilized in the development of stable dosage forms, such as tablets or capsules, for clinical trials.
• Biochemical Pathway Analysis: A critical tool for studying sarcomere function and the regulation of myocardial contractility at the molecular level.

Basic Information

Product Name	Danicamtiv
CAS No.	1970972-74-7
Molecular Formula	C₂₆H₂₈N₆O₃
Molecular Weight	472.54 g/mol
Synonyms	MYK-491; Danicamtiv Hydrochloride; (R)-2-(4-(4-(3-(2,6-Dimethylphenoxy)propyl)piperazin-1-yl)phenyl)-N-(5-methyl-1H-pyrazol-3-yl)acetamide; CK-3773274; PF-602; Cardiac Myosin Activator MYK-491; BMS-986231 (related salt form)
EINECS	Contact for details

Quality Control

Our Danicamtiv is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) confirming identity, purity (>98%), and specification compliance is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Assay (HPLC)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.