Description

Isopropyl (((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate Fumarate is a high-purity, advanced pharmaceutical intermediate and prodrug candidate. This compound matters for its role in the targeted delivery and activation of nucleotide analogs, a critical mechanism in modern antiviral and oncology therapeutics. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antiviral drugs, particularly for hepatitis B (HBV) and other viral infections, as well as in nucleotide-based cancer therapies.

Application

• Key Intermediate for Antiviral Prodrugs: Serves as a critical building block in the synthesis of advanced nucleotide prodrugs, such as those targeting hepatitis B virus (HBV).
• Pharmaceutical Research & Development: Used in preclinical and clinical research to study the pharmacokinetics, metabolism, and efficacy of novel nucleotide analog therapies.
• Oncology Drug Discovery: Employed in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in rapidly dividing cancer cells.
• Process Chemistry & Scale-Up: Utilized by process chemists for the optimization and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Acts as a precise biochemical tool in enzymology studies to investigate polymerase inhibition and nucleotide metabolism pathways.

Basic Information

Item	Detail
Product Name	Isopropyl (((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate Fumarate
CAS No.	1962114-89-1
Molecular Formula	C24H31N6O8P
Molecular Weight	562.52 g/mol
Synonyms	Isopropyl D-alaninate, (((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-, (2E)-2-butenedioate (1:1); GS-7340 Fumarate; Tenofovir Alafenamide Fumarate Intermediate; Isopropyl (((((S)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Fumarate; TAF Fumarate Intermediate; 1962114-89-1; Phosphonic acid, [[(1S)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl](phenoxy)-, (2R)-1-methylethyl ester, (2E)-2-butenedioate (1:1)
EINECS	Contact for details

Quality Control

Our Isopropyl (((((S)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate Fumarate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, consistent with standards for pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and residual solvents are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.