Description

(Des-Gly10,D-Leu6,[13C6]Leu7,Pro-Nhet9)-Lhrh is a stable isotope-labeled analog of a Gonadotropin-Releasing Hormone (GnRH) peptide, specifically designed for use as an internal standard in quantitative bioanalytical mass spectrometry. This compound is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies, providing a definitive reference for quantification. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced peptide hormone research and bioanalytical method development.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard (SIL-IS) for the precise LC-MS/MS quantification of native GnRH analogs in complex biological matrices like plasma and serum.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion for GnRH-targeting therapeutic peptides.
• Method Development and Validation: Essential for developing, optimizing, and validating robust, GLP-compliant analytical methods in regulated bioanalytical laboratories.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based assays.
• Preclinical and Clinical Research: Supports drug discovery and development programs for conditions treated with GnRH modulation, such as certain cancers and endocrine disorders.
• Quality Control in Manufacturing: Can be utilized in analytical procedures to ensure the purity and consistency of GnRH-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(Des-Gly10,D-Leu6,[13C6]Leu7,Pro-Nhet9)-Lhrh
CAS No.	1926163-75-8
Molecular Formula	C58H8313C6N17O13
Molecular Weight	Contact for details
Synonyms	Stable Isotope-Labeled GnRH Analog; [13C6]Leu7-GnRH Fragment; Deuterated/13C-Labeled LHRH Analog; Internal Standard for GnRH Quantitation; Gonadorelin (Des-Gly10, D-Leu6, [13C6]Leu7, Pro-NHEt9) analog; Luteinizing Hormone-Releasing Hormone (D-Leu6, 13C6-Leu7) derivative; Peptide IS for Bioanalysis; CAS 1926163-75-8
EINECS	Contact for details

Quality Control

Every batch of (Des-Gly10,D-Leu6,[13C6]Leu7,Pro-Nhet9)-Lhrh is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive mass spectrometry applications. Comprehensive testing includes identity confirmation, assay/purity by HPLC, and verification of isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (Enrichment)	≥ 98 atom % 13C
Water Content (KF)	≤ 5.0 %
Peptide Content	≥ 80% (by weight)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.