Description

([Ring-D5]Phe8)-Angiotensin II Acetate Salt is a high-purity, isotopically labeled analog of the potent vasoconstrictor peptide Angiotensin II, specifically deuterated at the phenylalanine-8 position. This compound is essential for advanced biomedical research, particularly in quantitative mass spectrometry, where it serves as a critical internal standard for precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular research, hypertension, and the renin-angiotensin system.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of native Angiotensin II in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug metabolism and disposition in preclinical and clinical studies targeting the renin-angiotensin-aldosterone system (RAAS).
• Proteomics and Metabolomics Research: Facilitates absolute quantification in targeted proteomic assays to study peptide hormone dynamics and pathway regulation.
• Method Development and Validation: Critical for developing and validating robust, GLP-compliant bioanalytical methods in drug discovery and development pipelines.
• Biomarker Discovery and Verification: Supports the discovery and verification of peptide biomarkers related to cardiovascular diseases and other endocrine disorders.

Basic Information

Product Name	([Ring-D5]Phe8)-Angiotensin II Acetate Salt
CAS No.	1926163-73-6
Molecular Formula	C50H68D5N13O12 • (C2H4O2)x
Molecular Weight	~1046.2 (free base) + acetate
Synonyms	Deuterated Angiotensin II (Phe8-D5); [Phe(D5)8]-Angiotensin II acetate; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe(D5)-OH acetate; DRVYIHPF(D5) acetate; Ang II-D5 acetate; Isotope-labeled Angiotensin II; Stable isotope-labeled internal standard for Ang II; AII-D5 acetate salt
EINECS	Contact for details

Quality Control

This high-value reference material is produced under stringent quality controls to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including HPLC, mass spectrometry, and NMR. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment, peptide content, purity, and acetate salt content, supporting traceability and method validation for regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	1.0 - 3.0 equivalents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.