Description

Acid-Peg9-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester group and a carboxylic acid terminus. This compound is engineered to facilitate the stable conjugation of biomolecules, such as proteins and peptides, to surfaces or other molecules under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, diagnostics, and therapeutic development, where precise and stable linker chemistry is required.

Application

• Bioconjugation Reagent: For covalently linking amine-containing biomolecules (e.g., antibodies, peptides) to carboxylated surfaces, particles, or other molecules.
• PEGylation Chemistry: Used to introduce a hydrophilic, flexible PEG spacer arm to drugs, proteins, or nanoparticles to improve solubility, stability, and circulation time.
• Diagnostic Assay Development: Key component in the fabrication of biosensors, microarrays, and immunoassay platforms by immobilizing capture molecules.
• Drug Delivery Systems: Facilitates the creation of antibody-drug conjugates (ADCs) or polymer-drug conjugates for targeted therapeutic delivery.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, or magnetic beads for specific biomedical and research applications.
• Materials Science: Used to create PEG-based hydrogels or functionalized polymers with specific bioactive properties.

Basic Information

Product Name	Acid-Peg9-Nhs Ester
CAS No.	1895916-27-4
Molecular Formula	C31H55NO16
Molecular Weight	697.8 g/mol
Synonyms	α-Acetic acid-ω-NHS ester nonaethylene glycol; NHS-PEG9-COOH; Carboxymethyl-PEG9-NHS ester; N-Hydroxysuccinimide ester of PEG9-acetic acid; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21,24,27-nonaoxanonacosan-29-oate; HOOC-PEG9-NHS; PEG9 spacer, NHS/COOH; 29-Carboxy-3,6,9,12,15,18,21,24,27-nonaoxanonacosanoic acid N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our Acid-Peg9-Nhs Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed by NMR and HPLC to confirm identity, purity, and the absence of critical impurities like free acid or diol. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.