Description

Diisopropyl 2,2'-((((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphoryl)Bis(Azanediyl))(2S,2'S)-Dipropionate Compound With Methane (1:1) is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel nucleotide analogs and prodrugs. This compound is critical for research and development in antiviral and anticancer therapies, offering a sophisticated chemical scaffold for targeted drug design. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleoside chemistry and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of next-generation antiviral and anticancer nucleotide prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel therapeutic agents targeting viral polymerases.
• Prodrug Development: Serves as a precursor for phosphoramidate and phosphonate prodrugs, enhancing cellular uptake and bioavailability of active metabolites.
• Biochemical Research: A tool compound for studying enzyme kinetics and inhibition mechanisms, particularly relevant to virology and oncology.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Item	Details
Product Name	Diisopropyl 2,2'-((((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphoryl)Bis(Azanediyl))(2S,2'S)-Dipropionate Compound With Methane (1:1)
CAS No.	1883563-86-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl)bis((2S)-2-methylpropanoate) compound with methane (1:1); Diisopropyl ((((R)-1-(6-Aminopurin-9-yl)propan-2-yl)oxy)methyl)phosphoramidate compound with methane; Methane adduct of Diisopropyl ((((R)-1-(6-Aminopurin-9-yl)propan-2-yl)oxy)methyl)phosphoramidate; Nucleoside Phosphoramidate Intermediate; Isopropyl Phosphoramidate Prodrug Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Diisopropyl 2,2'-((((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphoryl)Bis(Azanediyl))(2S,2'S)-Dipropionate Compound With Methane (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for advanced research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.