Description

4-Chloro-2,3-Difluoro-5-Methoxybenzoic Acid is a high-purity, multi-functional aromatic carboxylic acid derivative distinguished by its unique halogen and methoxy substitution pattern. This compound serves as a critical advanced intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials that require a precisely functionalized benzoic acid scaffold.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in fluorinated quinoline, quinolone, and other heterocyclic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoro and methoxy groups confer specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials.
• Organic Synthesis Reagent: Employed in coupling reactions (e.g., Suzuki, amidation) to introduce a functionalized benzoic acid moiety into larger molecular architectures.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry and material science research exploring structure-activity relationships (SAR).

Basic Information

Product Name	4-Chloro-2,3-Difluoro-5-Methoxybenzoic Acid
CAS No.	1879026-31-9
Molecular Formula	C8H5ClF2O3
Molecular Weight	222.57 g/mol
Synonyms	5-Methoxy-4-chloro-2,3-difluorobenzoic acid; 4-Chloro-2,3-difluoro-5-methoxybenzoic acid; Benzoic acid, 4-chloro-2,3-difluoro-5-methoxy-; 2,3-Difluoro-4-chloro-5-methoxybenzoic acid; 4-Chloro-2,3-difluoro-5-anisic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluoro-5-Methoxybenzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.