Description

Nicotinamide Adenine Dinucleotide (NAD+), Ammonium Salt (Ribose-13C5, 98%) is a high-purity, isotopically labeled coenzyme essential for metabolic research and pharmaceutical development. This compound, with a chemical purity of 96%, is specifically enriched with carbon-13 on the ribose moiety, making it an invaluable internal standard and tracer for mass spectrometry-based studies. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in advanced metabolomics, enzyme kinetics, and drug discovery programs focused on aging, neurodegeneration, and energy metabolism.

Application

• Metabolomics & Stable Isotope Tracing: Used as a 13C-labeled internal standard for the precise quantification of NAD+ and its metabolites (e.g., NADH, NADP+) in complex biological samples via LC-MS/MS.
• Enzyme Activity & Mechanism Studies: Essential for investigating the kinetics and mechanisms of dehydrogenases, sirtuins, PARPs, and other NAD+-dependent enzymes.
• Pharmaceutical R&D: Serves as a critical reagent in high-throughput screening assays for drug candidates targeting NAD+-consuming pathways in cancer, aging, and metabolic disorders.
• Biochemical Research: A fundamental cofactor for in vitro reconstitution of metabolic pathways and studies of mitochondrial function and redox biology.
• Diagnostic Kit Development: Employed as a calibrated standard in the development of clinical diagnostic kits for assessing cellular energy status and enzymatic deficiencies.

Basic Information

Item	Detail
Product Name	Nicotinamide Adenine Dinucleotide (NAD+), Ammonium Salt (Ribose-13C5, 98%) Chemical Purity 96%
CAS No.	1859096-06-2
Molecular Formula	C21¹³C5H32N7O14P2 • xNH3
Molecular Weight	Contact for details
Synonyms	NAD+ Ammonium Salt (Ribose-13C5); β-NAD+ (Ribose-13C5) Ammonium Salt; Coenzyme I (13C5-labeled); Diphosphopyridine Nucleotide (DPN+, 13C5); Oxidized Nicotinamide Adenine Dinucleotide (13C5); 13C5-NAD+; NAD+ (13C5, 98%); 1,4-Dihydronicotinamide adenine dinucleotide precursor (isotopic)
EINECS	Contact for details

Quality Control

Every batch of our 13C-labeled NAD+ Ammonium Salt is manufactured and tested under strict quality protocols to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing results for assay, isotopic purity, and key impurities. Our quality system is designed to support GLP/GMP-compliant research, and custom specifications can be accommodated upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 96.0% (Chemical Purity)
Isotopic Enrichment (Ribose-13C5)	≥ 98 atom % 13C
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.