Description

Methyl 2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoate is a high-value fluorinated pyrrolidine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecules, particularly for pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the life sciences industry seeking to incorporate its unique trifluoromethyl-substituted aromatic and pyrrolidine motifs into novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of drug candidates, especially in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: The pyrrolidine nitrogen acts as a coordination site for designing novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Library Synthesis: A valuable scaffold for constructing diverse compound libraries in high-throughput screening for drug discovery.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological studies and custom synthesis projects.

Basic Information

Product Name	Methyl 2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoate
CAS No.	1858257-29-0
Molecular Formula	C12H12F3NO2
Molecular Weight	259.23 g/mol
Synonyms	Methyl 2,3,5-trifluoro-4-(pyrrolidin-1-yl)benzoate; 4-(Pyrrolidin-1-yl)-2,3,5-trifluorobenzoic Acid Methyl Ester; 2,3,5-Trifluoro-4-(1-pyrrolidinyl)benzoic Acid Methyl Ester; Benzoic acid, 2,3,5-trifluoro-4-(1-pyrrolidinyl)-, methyl ester; Methyl 4-(pyrrolidin-1-yl)-2,3,5-trifluorobenzoate; 1-Pyrrolidinyl-2,3,5-trifluoro-4-methoxycarbonylbenzene
EINECS	Contact for details

Quality Control

Our Methyl 2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.