Description

Methyl 2,3,5-Trifluoro-4-(4-Methylpiperazin-1-Yl)Benzoate is a high-value fluorinated piperazine benzoate derivative, serving as a critical building block in advanced organic synthesis. This compound is essential for research and development in the pharmaceutical sector, where its unique trifluoromethyl and piperazine motifs are leveraged to modulate the biological activity and pharmacokinetic properties of new chemical entities. It is primarily sought after by medicinal chemists and process development scientists working on novel therapeutics, including kinase inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly for targeted cancer therapies and neurological drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize lead compounds due to its fluorine atoms and heterocyclic amine group.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of complex drug candidates.
• Biochemical Tool Compound: Potential use in biochemical assays as a probe or reference standard to study specific enzyme interactions.
• Agrochemical Research: May find application in the synthesis of novel agrochemicals, where the fluorine substitution can enhance stability and bioactivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized fluorinated building blocks.

Basic Information

Product Name	Methyl 2,3,5-Trifluoro-4-(4-Methylpiperazin-1-Yl)Benzoate
CAS No.	1858256-51-5
Molecular Formula	C13H14F3N2O2
Molecular Weight	290.26 g/mol
Synonyms	Methyl 2,3,5-Trifluoro-4-(4-methyl-1-piperazinyl)benzoate; 4-(4-Methylpiperazin-1-yl)-2,3,5-trifluorobenzoic Acid Methyl Ester; 2,3,5-Trifluoro-4-(4-methylpiperazin-1-yl)benzoic Acid Methyl Ester; Benzoic acid, 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-, methyl ester; MFCD30533366
EINECS	Contact for details

Quality Control

Our Methyl 2,3,5-Trifluoro-4-(4-Methylpiperazin-1-Yl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.