Description

3-Keto Sphinganine (D8:0) Hydrochloride is a deuterated, high-purity sphingolipid intermediate essential for advanced metabolic and biochemical research. This compound serves as a critical analytical standard and precursor for investigating sphingolipid biosynthesis, signaling pathways, and related disease mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on lipidomics and biomarker discovery.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the precise quantification of sphinganine and related sphingolipids in complex biological matrices.
• Biochemical Research: A key precursor in the study of the *de novo* sphingolipid synthesis pathway, particularly for investigating the enzyme serine palmitoyltransferase (SPT).
• Metabolic Pathway Tracing: Enables stable isotope labeling studies to trace metabolic flux and turnover rates in cellular and *in vivo* models.
• Pharmaceutical Development: Supports drug discovery programs targeting sphingolipid metabolism for conditions like cancer, neurodegenerative diseases, and metabolic disorders.
• Diagnostic Assay Development: Employed in the development and calibration of clinical assays for measuring sphingolipid levels as potential disease biomarkers.
• Lipidomics Reference Material: Provides a high-purity reference point for profiling and validating sphingolipid species in mass spectrometry-based lipidomic platforms.

Basic Information

Product Name	3-Keto Sphinganine (D8:0) Hydrochloride
CAS No.	1824382-78-6
Molecular Formula	C18H33D8NO3 • HCl
Molecular Weight	Contact for details
Synonyms	3-Ketodihydrosphingosine (D8) hydrochloride; (2S,3R)-2-Amino-3-hydroxyoctadecane-1-one-1,1,2,3,4,5,6,7-D8 hydrochloride; Deuterated 3-Keto Sphinganine HCl; 3-Ketosphinganine (D8:0) HCl; D8-3-Keto Dihydrosphingosine hydrochloride; 3-Oxosphinganine (D8) hydrochloride; Sphingolipid Intermediate D8 Standard
EINECS	Contact for details

Quality Control

Our 3-Keto Sphinganine (D8:0) Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive analytical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identity confirmation. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the rigorous standards expected in pharmaceutical and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container sealed in a secondary, moisture-proof barrier. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Enrichment (D8)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.